The Man with the Yellow Hat is about to become the world's first untrained person to fly into space so he can deliver food along with several experimental capsules to the International Space Station. But the spaceship designed by Professor Wiseman's assistants Professor Anthony Pizza and Dr. Alvin Einstein is only designed for someone with four hands. So, George winds up being the world's first monkey in space. George is told that he must activate the system that releases the goods for the station at a certain point and that his spaceship is in an orbit around the earth so he will eventually get back around to the station.