Jennifer Aniston (Series Premiere)

Megan Mullally

Sean Hayes/Nikki Reed

Amanda Bynes/Sharon Stone/Thicke

Jennifer Love Hewitt/John C. McGinley

Peter Boyle/Eve

Terry Bradshaw/Kim Cattrall/Seal

Noah Wyle/Bob Guiney/Elton John

Sean Astin/Breckin Meyer

Richard Simmons/Randy Jackson

Neve Campbell/Ruben Studdard

Merv Griffin/Topher Grace

Jessica Capshaw/The Thrills

Kim Cattrall/Bobby J. Thompson

Betty White/Amy Smart/Gavin DeGraw

Burt Reynolds/Nick Gannon

Ashton Kutcher/Deidre Hall/Travis

Julie Bowen/Fefe Dobson

Amy Brenneman and LeAnn Rimes

Katey Segal/Chris Harrison/Brian McKnight

Seth Green/Tyra Banks

Charlize Theron/Brook Shields

Diane Lane/Missy Elliot

Naomi Watts/Shoshana Johnson/Five For Fighting

Meg Ryan/Jason Lewis/The Indigo Girls

Jessica Simpson / Nick Lachey / Henry Winkler

Sarah Michelle Gellar/Olivier Martinez/Brad Paisley

Ben Affleck/Sara Rue

Katie Holmes, Black Eyed Peas

Season 1 Halloween Show: Ellen as Dr. Phil

Kiefer Sutherland, Jane Leeves

Jeff Bridges, Doris Roberts

Steve Harvey, Rod Stewart

Holly Hunter, Sarah McLachlan, Jeff Corwin

Lauren Graham, Frankie Muniz

Brendan Fraser, John Stamos

Queen Latifah, Sheryl Crow

Eric McCormack, Paul Walker

Jenna Elfman, Cyndi Lauper

Bernie Mac, Valerie Bertinelli

Robert Downey Jr., Mary J. Blige

Bette Midler, Bob Guiney

Dwayne The Rock Johnson, Jami Gertz

David Duchovny, Poppy Montgomery

Anne Hathaway, Cedric the Entertainer

Jessica Simpson & Nick Lachey, Henry Winkler, Hugh Dancy

Elisha Cuthbert, Dennis Franz

Barry Manilow, Nia Vardolas, Baby Birds

Janet Jackson, David Arquette, Ellen's Own Award Show

John Travolta, Goran Visnjic, Random Acts of Kindness

Tina Fey, David Bowie, Ellen's 'In Case of Emergency'

Isabella Rossellini, Debbie Reynolds, Bill Rancic

Simon Baker, Cheri Oteri

Christopher Walken, Tim Meadows

Jennifer Garner, Jamie Kennedy

Dakota Fanning, Rebecca Romijn, Feline Reunion

Bill Cosby, Sarah Chalke

Mary Tyler Moore, Rosie Perez, Hidden Talents

Jay Leno, Lorraine Bracco

Lindsay Lohan, Kevin Sorbo, Ending of ‘Friends’

Hugh Jackman, Al Roker, Car Giveaway

Josh Duhamel, Christina Ricci

David Schwimmer from ‘Friends,’ Gabrielle Union

Patti LaBelle, Cynthia Nixon

Usher, Patrick Stewart, Cooking with Nigella Lawson

Paula Abdul, Wilmer Valderrama

David Spade, Latoya London, Vanessa Marcil

Simon Cowell, Jorja Fox

Dolly Parton, Jon Favreau, Workout Attire

Glenn Close, Andy Richter

Jake Gyllenhaal, Sean Hayes, 8-Year-Old Drummer

Antonio Banderas, Alanis Morissette

Cameron Diaz, Cotton Candy

Halle Berry, Tom Selleck

Kate Hudson, Julian McMahon

Justin Timberlake, Sharon Stone, Fantasia Barrino